Cover Feature: The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions. (Eur. J. Org. Chem. 20/2021)

The Cover Feature shows a combination that could be called the ugly duckling of Ugi 4-component reactions, which involves concomitant use ammonia/formaldehyde pair. There was not single methodology so far to successfully achieve this goal. metamorphosis finally happen with intermediacy hexamethylenetetramine (HMTA), allows in situ generation both ammonia and formaldehyde for reactions carboxylic acids isocyanides, yielding variety acylaminoacetamide derivatives good excellent yields. More information can found Full Paper by C. K. Z. Andrade et al.